The Effect of Fluvastation on the Proliferation of Blood Vessel Smooth Muscle Cell in Experimental Atherosclerosis Rabbits
- VernacularTitle:氟伐他汀对实验性动脉粥样硬化家兔血管平滑肌细胞增殖的影响
- Author:
Lin LU
;
Xinglei ZHU
;
Jing LUO
- Publication Type:Journal Article
- Keywords:
Fluvastatin;
Atherosclerosis;
Smooth muscle cell;
Proliferation;
Platelet derived growth factor
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of fluvastatin on the proliferation of blood vessel smooth muscle cell (SMC) and the expression of platelet derived growth factor-A(PDGF-A) in experimental atherosclerosis(As) rabbits. Methods The expression of proliferating cell nuclear antigen(PCNA) of SMC was detected by immunohistochemistry. The expression of PDGF-A protein and mRNA was determined using immunohistochemical method and RT-PCR, respectively. Results The pathological lesions of atherosclerosis in fluvastatin group was significantly milder than those in high fat diet group(P
