Demographic and clinical features of hereditary nonpolyposis colorectal cancer
- VernacularTitle:遗传性非息肉病性大肠癌家系的临床特征分析
- Author:
Xiaoxia LI
;
Jie GUO
;
Siping MA
;
Jingru ZHANG
;
Tao LIN
;
Weihong YU
;
Lan XU
;
Ying SHI
;
Shubao WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Hereditary nonpolyposis
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate demographic and clinical features of hereditary nonpolyposis colorectal cancer (HNPCC) in Chinese patients.Methods Data of 45 HNPCC pedigrees diagnosed in accordance with Armsterdam I and Armsterdam Ⅱ Criteria were collected and analyzed.Results In 264 patients, 305 malignant neoplasms were found.The median age of confirmed diagnosis of HNPCC was 50 years.Out of the 305 primary cancer foci, 180 were colonic cancers (59%), 125 were extracolonic cancer (41%) with carcinoma of the lung, endometrium and stomach accounting for 24.0% (30/125), 14.4% (18/125), and 12.0% (15/125) respectively.Conclusion HNPCC is characterized by early vertical transmission, with extracolonic cancer, and synchronous multiple and/or metachronous multiple primary cancers as common clinical features. Carcinoma of the lung, endometrium and stomach are among the most common extracolonic malignancies.
