Targeting therapy of magnetic doxorubicin stealth liposome on human gastric cancer xenografts in nude mice
- VernacularTitle:磁性阿霉素隐形脂质体对裸鼠移植性人胃癌的靶向治疗
- Author:
Yishu LIU
;
Liqing YAO
;
Pinghong ZHOU
;
Xizhong SHEN
;
Weiyue LU
;
Ming YAO
;
Zhijiang WU
;
Yajun SUN
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Liposome;
Doxorubicin
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of magnetic doxorubicin stealth liposome on human gastric cancer xenografts in nude mice.Methods Human gastric cancer cell line MKN-45 was implanted into 36 nude mice.Different kinds of drug were injected through the caudal vein of tumor bearing nude mice divided into 6 groups .Permanent magnet was put into tumor in targeting group.Results The growth speed of tumor in the group of MDL (+) significantaly slowed down than other groups.The rate of tumor restrain in tumor weight and tumor volume of MDL (+) group were 71% and 70%, which were remarkably higher than those of the DOX and MDL (-) group (all P
