Significance of expression of Flt-4 in different histopa thological grades of astrocytoma
- VernacularTitle:Flt-4在不同级别脑星形细胞瘤中的表达意义
- Author:
Xiufeng YE
;
Xueyun ZHONG
;
Can MI
;
Chipeng WU
- Publication Type:Journal Article
- Keywords:
Astrocytoma;
Fms-like tyrosine kinase 4;
Angi ogenesis, pathologic
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the significance of expressio n of fms-like tyrosine kinase 4 (Flt-4) in different histopathological grades of a strocytoma. METHODS: The surgical specimens from 50 brain astrocytoma patien ts were stained immunohistochemically for examining Flt-4 and vascular endotheli al growth factor (VEGF) expression. Intratumoral microvessel density (IMVD) was calculated by labeling the endothelial cells of the blood vessels within the tum or. RESULTS: Flt-4, VEGF expression were closely correlated with his topathological grades of astrocytoma. Flt-4 and VEGF expression were found in 52 % (26/50), 60% (30/50) of tumors. A significant correlation was found between Fl t-4 and VEGF expression (P
