Gene expression of 5?-reductase (type 2) in reproductive gland of pubertal diabetic rats
- VernacularTitle:青春期糖尿病大鼠生殖腺内5?-还原酶(2型)的基因表达研究
- Author:
Suhuan LIU
;
Zhongshan WANG
;
Zongge XU
;
Jili XIN
;
Wenjing ZUO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Oxidoreductases;
Reproduction
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the molecular mechanism of reproduction dysfunction in pubertal diabetic rat, the level of 5?-reductase (type 2) mRNA in testis, epididymis and prostate in diabetic rat was detected. METHODS: The gene expression of 5?-reductase (type 2) was detected by Northern blot. RESULTS: In the caput of the epididymis, the expression of 5?-reductase (type 2) mRNA of D and ID groups was less than that of C group. CONCLUSION: The decreased expression of 5?-reductase (type 2) results in the decreased production of dihydrotestosterone, which influences the development and function of reproduction system in pubertal rats. [
