Gene Expression of Transforming Growth Factor-?1 and Receptors in Psoriatic Skin
- VernacularTitle:银屑病患者皮损中转化生长因子-?1及受体基因表达的研究
- Author:
Chunfang GAO
;
Jun GU
;
Maorong ZHENG
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Transforming growth factor-beta;
Receptors transforming growth factor beta
- From:
Chinese Journal of Dermatology
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mRNA expression and function of TGF-?1, TGF-?RⅡ and CD105 in the lesional, non-lesional skin of psoriasis and of normal human skin. Methods The RNA of skin tissue was extracted using single-step method of RNA isolation by acid guanidinium thiocyanate. Reverse transcription polymerase chain reaction (RT-PCR) was used to measure the expression of mRNA. Results The mRNA expression of TGF-?1 and TGF-?RⅡ was lower in the epidermis of psoriatic lesion than that of non-lesional psoriatic and normal human skin(P
