Cyclooxygenase-2 expression of pancreatic tissues in severe acute pancreatitis in rats
- VernacularTitle:环氧合酶-2在重症急性胰腺炎大鼠胰腺组织中表达的实验研究
- Author:
Shanzheng CHEN
;
Yixiong LI
;
Xinshen LU
- Publication Type:Journal Article
- Keywords:
PANCREATITIS/pathol;
CYCLOOXYGENASE-2;
ACUTE DISEASES;
GENE EXPRESSION
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of cyclooxygenase-2(COX-2) in pancreatic tissues of severe acute pancreatitis(SAP) in rats,and explore the possible role of COX-2 in the pathogenesis of the SAP. Methods Forty adult male Sprague-Dawley rats were randomly divided into SAP group(n=20) and control group(n=20). At 12h after operation,acites,serum levels of amylase activity,tumor necrosis factor-?(TNF-?),TXB 2 and 6-keto-PGF 1? and the expression of COX-2 in pancreatic tissue were detected.the pathological changes of pancreatic tissues were observed and scored under microscope;the survival rate in 72h and mortality in 24h in SAP and NC group were recorded.Results At 12h after the induction of SAP,the serum amylase activity,TNF-?,TXB 2 and 6-keto-PGF 1? were significantly higher in SAP group than those in NC group(P
