The molecular mechanism of inhibition of murine Lewis lung carcinoma metastasis by weimaining in vivo
- VernacularTitle:威麦宁抗小鼠Lewis肺癌转移作用及分子机制的研究
- Author:
Jinli LOU
;
Hongsheng LIN
;
Quanying QIU
;
Yingxia PEI
;
Xin QI
;
Xiujuan HE
- Publication Type:Journal Article
- Keywords:
Weimaining;
Neoplasm metastasis;
Cadherins;
Antigens, CD34
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the anti-metastasis effect of weimaining, extracted from fragopyrum cymosum meissn, a Chinese medicine, on murine Lewis lung carcinoma (3LL). METHODS: The anti-metastasis effect of weimaining in vivo was detected in the grafting lung metastasis model of murine Lewis lung carcinoma. The effects of the drug on the expression of CD34 and E-cadherin were investigated by immunohistochemical staining and RT-PCR. RESULTS: Weimaining effectively inhibited the lung metastasis of 3LL at a concentration of 250 mg?kg -1?d -1, significantly suppressed the expression of CD34 and increased the expression levels of E-cadherin protein and mRNA in 3LL cells. CONCLUSIONS: Weimaining inhibits the metastasis of murine Lewis lung carcinoma (3LL) in vivo via increasing the expression of E-cadherin and decreasing microvessel density of tumor tissue.
