Expression of local renin and angiotensinogen mRNA in cirrhotic portal hypertensive patients
- VernacularTitle:局部肾素与血管紧张素原mRNA在肝硬化门静脉高压症患者中的表达及其意义
- Author:
Li ZHANG
;
Zhen YANG
;
Chongyun FANG
;
Xiaoyong WU
;
Dapeng LI
- Publication Type:Journal Article
- Keywords:
Cirrhosis;
Hypertension, portal;
Renin;
Angiotensinogen
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of portal hypertension (PH) on the activity of local renin angiotensin system(LRAS). Method The expression of local renin and local angiotensinogen mRNA in liver,splenic artery and vein of PH patients was detected with RT-PCR. Result Expression of local renin mRNA in the liver in control group was 0.19?0.12, significantly lower than that of splenic artery (0.45?0.12) and splenic vein (0.39?0.12) respectively(P
