Changes of CD28, CD56 and CD57 expression on CD8+T cells in the peripheral blood of healthy elderly individuals
- VernacularTitle:人外周血CD8~+T细胞CD28、CD56及CD57表达水平的老年性改变
- Author:
Haixia QIU
;
Xianhui HE
;
Yi LIU
;
Xiaochang CAI
;
Jingxian ZHAO
;
Nan WANG
;
Yaoying ZENG
- Publication Type:Journal Article
- Keywords:
Immunosenescence;
T-lymphocytes;
Antigens,CD28;
Flow cytometry
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The expression of CD28, CD56 and CD57 on CD8+T cells in the peripheral blood of young (age range 20-35) and elderly(age range 60-75) healthy donors were compared to explore the change of the cellular immune function with aging.METHODS: Three-color fluorescent flow cytometry was performed to analyze the differences in percentage of CD8+CD28+, CD8+CD56+ and CD8+CD57+T cells in the peripheral blood between the young and elderly groups.RESULTS: CD8+CD28+T cells in the peripheral blood of the elderly group was significantly lower than those in the young group, with percentage of 34.07?5.28 and 49.84?7.43,respectively (P
