The experimental study on rhBMP-2 combined with type I collagen as pulp capping agent in cats
- VernacularTitle:重组人骨形成蛋白-2复合胶原I盖髓的实验研究
- Author:
Shiguang HUANG
;
Min XIE
;
Huadong WANG
;
Tie CHEN
;
Ning ZHANG
- Publication Type:Journal Article
- Keywords:
Bone morphogenetic proteins;
Collagen;
Dentin;
Osteocalcin
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To assess the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with type I collagen on pulp capping in cats. METHODS: Freshly exposed pulps of thirty cats were capped with four different pulp capping agents: rhBMP-2/collagen I, calcium hydroxide, type I collagen and bovine serum albumin as control. The reparative dentinogenesis and osteocalcin content were assessed after 1 week, 2 weeks and 4 weeks by means of histology and radioimmunoassay. RESULTS: the pulpal tissues of the teeth capped with rhBMP-2/collagen showed mild inflammation and odontoblast differentiation with tublar dentin bridge on the exposed site. The level of bone ?-carboxyglutamic containing protein(BGP) in the group of rhBMP-2 with collagen I was significantly higher than that of the other three groups (P
