Screening the Formulae of Norfloxacin Zinc Granules Using Uniform Design
- VernacularTitle:均匀设计法筛选诺氟沙星锌颗粒的处方
- Author:
Shenghao WANG
;
Fang LIN
;
Junbin ZUO
- Publication Type:Journal Article
- Keywords:
uniform design;
granules;
norfloxacin zinc
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To screen the formulae of norfloxacin zinc(NF-Zn) suspended granules using uniform design METHODS:The uniform design with 5 levels and 4 factors was employed to screen five formulae of NF-Zn and sedimentation rate,granularity,dissolubility,moisture content and taste of these granules were evaluated and scored The total score of each formula was regressed with the 4 factors by computer RESULTS:The results of regression equation suggested that the optimum formula was NF-Zn 0 2g,CMS-Na 0 25g,2%PVP and manitol 0 55g in each packet CONCLUSION:It is effective and convenient to optimize the formula of NF-Zn granules by uniform design
