Effects of CD40-CD40 ligand interaction on endothelial cell procoagulant activity
- VernacularTitle:CD40-CD40配体相互作用对内皮细胞促凝活性的影响
- Author:
Qiangjun CAI
;
Jilin CHEN
;
Hong ZHANG
;
Xiangfen CONG
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Endothelial cells;
Thromboplastin;
CD40 ligand
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effects of CD40-CD40 ligand (CD40L) interaction on endothelial cells (ECs) procoagulant activity. METHODS: A co-incubation system of macrophage membrane with ECs was established. The changes in ECs procoagulant activity and tissue factor (TF) expression were studied by anti-CD40L antibody blocking analysis. RESULTS: Coincubation with macrophage membrane (cell ratio 1∶1) for 6 hours resulted in a 10.9-fold increase ( P
