Regeneration of neuropeptide Y positive nerve fibers in splenic autotransplantation in rats
- VernacularTitle:自体移植脾组织神经肽Y阳性神经纤维再生的实验研究
- Author:
Kun ZHANG
;
Guangjin GUO
;
Pengfen GAO
;
Huiyang YU
;
Tianfei ZHANG
- Publication Type:Journal Article
- Keywords:
SPLEEN/tronspl;
TRANSPLANTANTION,AUTOLOGOUS,NEUROPEPTIDE-Y;
NERVE RIGENERATION
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the regeneration regularity of neuropeptide Y positive(NPY+) nerves in splenic autotransplantation. Methods Healthy Wistar rats were randomly divided into two groups:(1)splenectomy and splenic autotransplantation group;(2) sham-operation group. Regeneration process and density changes of the NPY+ nerve fibers in the two groups were studied by immunohistochemical methods and computer image analysis qualification on day 7, 14, 30, 60, 90, 120 and 180 postoperatively. Results The NPY+ nerve fibers had no regeneration on day 30 postoperatively, but on day 60 nerve fibers appeared in the peri-region of the autotransplanted spleen, on day 90 nerve fibers extended into the inner-part of splenic autotransplants. Density of the nerve fibers gradually became greater and almost normal on 180 days after operation. Conclusions After splenic autotransplantation, the NPY+ nerve fibers could be regeneration in the autotransplants tissue. The renascent nerve fibers came from greater omentum which wrapes the splenic autografts.
