Effect of PKC activition on cardiac myocyte apoptosis and Bcl-2 expression during myocardial ischemia/reperfusion in rats
- VernacularTitle:蛋白激酶C活化对大鼠缺血/再灌注心肌细胞凋亡和Bcl-2表达的影响
- Author:
Xingde LIU
;
Yunzhe CHEN
- Publication Type:Journal Article
- Keywords:
Myocardial reperfusion;
Cell death;
Gene expression;
Protein kinase C;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of PKC activition on cardiac myocyte apoptosis and expression of bcl-2 during myocardial ischemia/reperfusion(I/R) in rats. METHODS: TUNEL,immunohistochemistry and in situ hybridization were used. RESULTS: The TUNEL data showed that the numbers of positive cardiac myocyte nucleus and the percentage of positive cardiac myocyte nucleus in PMA+IR 3 h group decreased significantly( P
