Determination of the Concentrations of Ceftriaxone in Blood and Bile of Patients During Perioperative Period
- VernacularTitle:围术期患者血液及胆汁中头孢曲松钠浓度的测定
- Author:
Yuqin YIN
;
Liumeng YANG
;
Guili XU
;
Jing ZOU
- Publication Type:Journal Article
- Keywords:
ceftriaxone;
periopeartive period;
drug concentration in blood;
drug concentration in bile
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the anti-infective effect of ceftriaxone in perioperative period METHODS:28 cases of cholelithiasis complicating infections who had to undergo laparoscopic cholecystectomy were enrolled in this study Ceftriaxone,1g,im,was injected 1h～1 5h before anesthesia,and blood and bile were sampled before,during and after operation The concentration of ceftriaxone was determined by UV-spectrophotometry RESULTS:The concentrations of ceftriaxone in blood before,during and after operation were(37 59?16 13)?g/ml,(49 68?10 51)?g/ml and (27 09?12 38)?g/ml respectively The drug concentration in blood peaked 2h after drug administration,at this time,the drug concentration of bile was 4 times that of blood (201 77?20 16)?g/ml CONCLUSION:The drug concentration in blood was 49 times as high as MIC,which indicates that ceftriaxone has preventive and therapeutic effects on possible infections during perioperative period
