Effects of adrenomedullin on proliferation of vascular smooth muscle cells induced by urotensin Ⅱ
- VernacularTitle:肾上腺髓质素对尾加压素Ⅱ刺激的血管平滑肌细胞增殖的影响
- Author:
Yongfen QI
;
Chunfang XIA
;
Yahong CHEN
;
Lin XUE
;
Yongzheng PANG
;
Chaoshu TANG
- Publication Type:Journal Article
- Keywords:
Mitogens;
Protein kinases;
Muscle, smooth, vascular;
Urotensins;
Adrenomedullin
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of adrenomedullin(ADM)on proliferation of vascular smooth muscle cells(VSMC) induced by urotensin Ⅱ(UⅡ). METHODS: DNA synthesis of cultured rat aortic VSMC was measured by -TdR incorporation. The activities of mitogen activated protein kinase(MAPK) were determined by isotope tagged with [?- 32 P]-ATP. RESULTS: UⅡ(10 -8 mol/L) significantly increased -TdR incorporation of VSMC and MAPK activities by 38%( P0.05 ), 32%( P0.05 ), 32%( P
