Expression of nuclear factor-?B in asthmatic guinea pigs and the effect of erigeron breviscapus on it
- VernacularTitle:豚鼠哮喘模型核因子-?B的表达特点及灯盏花素对其作用的研究
- Author:
Weining XIONG
;
Yongjian XU
;
Zhenxiang ZHANG
;
Xiaoyang WANG
;
Biwen MO
;
Yipeng DING
;
Yi JIN
;
Shixin CHEN
- Publication Type:Journal Article
- Keywords:
NF-kappa B;
Protein kinase C;
Asthma
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the expression of nuclear factor-?B(NF-?B) in asthmatic guinea pigs, and the effect of erigeron breviscapus, a protein kinase C(PKC) inhibitor, on the expression of nuclear factor-?B(NF-?B). METHODS: 48 guinea pigs were randomly divided into 6 groups ( n= 8). Airway resistance and eosinophilic inflammation of airway wall were examined, the expression of NF-?B in the lung tissue was detected by immunohistochemical staining. RESULTS: The expression of NF-?B was mainly found in airway epithelium, all the asthmatic animals showed significantly higher optical densities than that of the normal control group( P
