Histomorphometry investigation and mechanism exploration of postmenopausal osteoporosis
- VernacularTitle:绝经后骨质疏松症模型体视学测量和机理初探
- Author:
Ziyi CHEN
;
Liantang WANG
;
Dong CHEN
;
Guodong CHEN
- Publication Type:Journal Article
- Keywords:
Osteoporosis, postmenopausal;
Ovariectomy;
Bone density
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the pathophysiological mechanism of postmenopausal osteoporosis, we established an animal model for postmenopausal osteoporosis and investigated the loss of bone mass.METHODS: Thirty-one female SD rats (three months old) were randomly divided into two groups: sixteen ovariectomized (OVX) and fifteen sham-operated group as control. At post-operated day 28, seven rats of either OVX group or sham-operated group were sacrificed. At post-operated day 56, the rest of either were sacrificed. The wet weight of the uteruses were measured and the changes of bone micro-architecture were studied by bone mineral density (BMD) and the data of bone histomorphometry. RESULTS: Compared with the sham group, the mean wet weight and the bone density of proximal tibia 1/3 section of the OVX group was significantly decreased (P
