Effects of ischemic preconditioning on cardiac myocyte apoptosis and expression of bcl-2 during myocardial ischemia/reperfusion in rats
- VernacularTitle:大鼠心肌缺血预适应对I/R心肌细胞凋亡及bcl-2表达的影响
- Author:
Xingde LIU
;
Yunzhe CHEN
- Publication Type:Journal Article
- Keywords:
Myocardium;
Ischemia;
Myocardioal reperfusion;
Apoptosis;
Gene expression;
Rats
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of ischemic preconditioning on cardiac myocyte apoptosis and the expression of bcl-2 during myocardial ischemia/reperfusion in rats. METHODS: We use TUNEL,immunohistochemical and in situ hybridization(ISH) methods to detect the cardiac myocyte apoptosis and the expression of bcl-2 during myocardial ischemia/reperfusion in rats. RESULTS:① The numbers of positive cardiac myocyte nuclear and the percentage of positive cardiac myocyte nuclear in IP+I/R 3h group decreased significantly(P
