Experimental study on setting up hypercapnic model and its pathophysiological changes in rats
- VernacularTitle:大鼠高碳酸血症模型的复制及其病理生理变化的实验研究
- Author:
Jianxin WANG
;
Chen WANG
;
Baosen PANG
;
Shujie NIU
;
Xinzhi WENG
;
Yanling MAO
;
Li MA
;
Xiuxia HUANG
;
Haiyan ZHANG
;
Ping XIN
- Publication Type:Journal Article
- Keywords:
Lung diseases, obstructive;
Hypercapnia;
Rats;
Lipid peroxidation
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To reproduce hypercapnic models and approach some pathophysiological changes in rats. METHODS: The mixed gases of high concentrated carbon dioxide (8% CO 2, 21% O 2, 71% N 2) were given to wistar rats 7 hours a day for 28 days. The various indexes were compared between control group (group A) and hypercapnic group (group B). RESULTS: The PaCO 2 [(55.90?4.34) mmHg] and the lipid peroxides (LPO) contents in plasma, lung tissue and right ventricle were significantly higher in group B than those in group A ( P
