Relationship between activity of matrix metalloproteinases-2 and invasion, metastasis of breast cancer
- VernacularTitle:基质金属蛋白酶-2酶活性与乳腺癌浸润、转移的关系
- Author:
Yuewu ZHAO
;
Yuanrui HAO
;
Pingzhang YIN
;
Lingfei KONG
;
Baomei WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Metalloproteinases;
Neoplasm metastasis
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate relationship between activity of matrix metalloproteinases-2 ( MMP-2, 72 kD) and invasion, metastasis of breast cancer. METHODS: Useing zymography and computer software assisted analysis, the activitive levels of MMP-2 (72 kD) in tissues from breast cancer were measeured. RESULTS: Mean activitive levels of MMP-2 72 kD (13.93?3.60) in breast cancer were lower than those in benign disease (21.43?8.31), P0.05) in MMP-2 62 kD+72 kD of benign and malignant disease, but MMP-2 62 kD (13.83?4.53) and MMP-2 62 kD/62 kD+72 kD(0.48) respectively were significantly higher in malignant disease (P
