Insulin influences the vasoconstriction caused by endothelin-1 in the hyperglycemic rat
- VernacularTitle:胰岛素对糖尿病大鼠内皮素缩血管作用的影响
- Author:
Yi DING
;
Jiafu WANG
;
Tongmei LIU
;
Wenzuo DUAN
;
Xiuyuan SONG
;
Jianling GONG
- Publication Type:Journal Article
- Keywords:
Insulin;
Endothelins;
Aorta;
Hyperglycemia
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of insulin on aortic constriction caused by endothelin-1(ET-1) in normal and hyperglycemic rats. METHODS: Hyperglycemic rat models were prepared. Two aortic rings were immersed in the Krebs-Hensleit fluid with and without insulin (40 mIU/L) and the responses of rings to 10 -9 mol/L ET-1 were observed. RESULTS:ET-1 induced more obvious aortic ring constriction in normal rats than those in hyperglycemic rats ( P
