Effect of bFGF on expression of endothelial cell integrin ?_1 subunits
- VernacularTitle:bFGF促进内皮细胞?_1整合素表达及其意义探讨
- Author:
Xulong ZHOU
;
Yipin DENG
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor,basic;
Integrins;
Neovascularization
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of basic fibroblast growth factor(bFGF) to the expression of integrin ? 1 subunit of endothelial cells. METHOD: The expression of integrin ? 1 subunit of endothelial cells was determined before and after bFGF treatment with Western Blot and immage analysis method.RESULTS: The mean gray value of immunostain by immage analysis method is 166.11?9.86 in the experimental group and 175.32?5.12 in the control group, suggested that bFGF may upregulate expression of integrin ? 1 subunits of endothelial cell. CONCLUSION: bFGF may play an important role in angiogenesis by way of inducing the overexpression of endothelial cell integrin ? 1 subunits.
