The effects of calcium and reactive oxygen species in rat kidney during ischemia and reperfusion period
- VernacularTitle:钙及活性氧在大鼠肾缺血再灌流损伤中的作用
- Author:
Jihong SHA
;
Xuting YE
;
Lili WU
;
Yue WU
;
Yongji YAN
;
Zun ZHEN
- Publication Type:Journal Article
- Keywords:
Ischemia;
Reperfusion;
Calcium;
Oxygen
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: Electron cytochemical methods were used to study the changes of calcium and reactive oxygen species in rat kidney during ischemia and reperfusion period.RESULTS:By the end of 1h ischemia, intra-cellular calcium increased. There were no H 2O 2 generation at this time. In the early reperfusion period, large amount of H 2O 2 generated. At this time, there were no evident changes of intra-cellular calcium compare with 1h ischemia group. In the later reperfusion period, less H 2O 2 generated. Intra-cellular calcium increased continuously.CONCLUSION:Calcium and reactive oxygen species all participated in ischemia-reperfusion injury, but the time they participated and their effects were different.
