Relationship between erythrocyte rheological properties and RBC superoxide dismutase，plasma malondialdehyde level in patients with high altitude polycythemia
- VernacularTitle:高原红细胞增多症患者红细胞流变性与红细胞SOD、血浆MDA关系的研究
- Author:
Aiqi XI
- Publication Type:Journal Article
- Keywords:
Altitude;
Polycythemia: Malondialdehyde;
Superoxide dismutase;
Erythrocytes;
Rhelology
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the relationShip between erythrocyte rheological properties and lipid peroxidation in patients with high altitude polycythemia (HAPC). METHODS: Erythrocyte filtration index (EFI), RBC immune function, RBC superoxide dismutase (RBC - SOD) and plasna malondialdehyde (MDA) in 86 patients with HAPC and 88 healthy subjects at different altitudes (3300 m or 4080 m) were measured.RESULTS: EFI, RBC immune complex flower rate (RBCICFR) and plasma MDA level were increased, RBC - SOD and RBC C3b receptor flower rate (RBC C3b RFR )were decreased in pattenes with HAPC. There were masked difference between HAPC patients and healthy subjects. With increasing altitude, EFI, RBCICFR and plasma MDA level in HAPC patients were in- creased markedly, but RBC - SOD and RBC C3b RFR were decreased obviously. RBC - SOD was in negative corre- laton with EEI and RBCICFR, and positive correlation with RBCC3bRFR.Relationship betWeen plasma MDA level and hove mentioned para - meters were reversed. CONCLUSION: Lipid peroxidation in patients with HAPC were increased with increasing altitudes, which may be an important cause of decreasing erythrocyte deformability.
