Effect of contact system in monocyte adhesion induced by urokinase-type plasminogen activator
- VernacularTitle:内源性接触激活系统对单核细胞粘附的影响
- Author:
Jianxia LIU
;
Jianling ZUO
;
Lei QIN
;
Haixin QIAN
;
Jianning LIU
- Publication Type:Journal Article
- Keywords:
Urokinase;
Monocytes;
Cell adhesion
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the effect of contact system in monocyte adhesion induced by urokinase-type plasminogen activator (U-PA). METHODS:U937 cells were labeled with [3H] thymidine in the culture medium, test reagents were added into the cell suspension in 24-well plates. The counts?min -1 were counted in a liquid scintillation counter. RESULTS:U-PA-induced monocyte adhesion was inhibited by high-molecular-weight kininogen and kallikrein, and promoted by factor Ⅻ and plasminogen. CONCLUSION:these contact system proteins may be important modulators of U-PA-induced monocyte adhesion, a process which is involved in many pathophysiological events.
