The changes of specific binding sites of glucocorticoid after scalding in rats
- VernacularTitle:大鼠烫伤后肝胞液糖皮质激素特异结合部位的变化
- Author:
Yingying LE
;
Renbao XU
- Publication Type:Journal Article
- Keywords:
Glucocorticoids;
Bindidg sites;
Liver;
Burns
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The binding capacity (R_o) and apparant dissociation constant (K_d) of glucocrticoid binding sites in hepatic cytosol of normal and scalded rats were measured by pseudoscatchard analysis. Compared with control group, the levels of Ro of glucocorticoid receptor was significantly decreased 1 h after scalding, partialy recovered at 12h after scalding and fully recovered at 24 h after scalding. The levels of low-affinity glucocorticoid binding sites were also decreased 12 h after scalding, but had no statistical significance. The possible significance of these results has been discussed.
