Correlation Study Between Angiotensin II Type1 Receptor Autoantibodies and the Onset Risk in Patients With Essential Hypertension Combining Acute Coronary Syndrome
10.3969/j.issn.1000-3614.2017.02.009
- VernacularTitle:抗血管紧张素Ⅱ 1型受体自身抗体与原发性高血压患者合并急性冠状动脉综合征发病风险的分析
- Author:
Yanxiang SUN
;
Jun TAO
;
Li FENG
;
Yong YUAN
;
Xuansheng HUANG
;
Liting ZHANG
- Keywords:
Acute coronary syndrome;
Hypertension;
C-reactive protein;
Autoantibody
- From:
Chinese Circulation Journal
2017;32(2):149-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the correlation between angiotensin II type1 receptor autoantibodies (AT1-AAs) and the onset risk in patients with essential hypertension (EH) combiningacute coronary syndrome (ACS). Methods: Our research included in 4 groups: EH+ACS group,n=28, ACS group, n=29, EH group,n=26 and Control group,n=23 normal subjects. Serum levels of AT1-AAs were examined by ELISA; high sensitivity C-reactive protein (hs-CRP), blood levels of lipids and glucose were also measured and compared among different groups. The correlations between AT1-AAs and blood lipids, glucose, hs-CRP were studied by multiple linear regression analysis. Results: Compared with Control group, ACS group had similar level of AT1-AAs (0.26±0.09) vs (0.21±0.06),P=0.105; while EH+ACS group and HE group had increased AT1-AAs level as (0.40±0.005) and (0.33±0.10),P=0.001 andP=0.02 respectively; AT1-AAs level was higher in EH+ACS group than HE group,P=0.044. In addition, serum AT1-AAs level was positively related to hs-CRP in EH+ACS group, ACS group and EH group (r=0.589,r=0.503 andr=0.273, allP<0.01). Conclusion: Serum AT1-AAs level was positively related to the onset risk in patients with EH combining ACS; AT1-AAs was also related to hs-CRP at certain degree.
