Efficacy of nalmefene in preventing sufentanil-induced cough during induction of general anesthesia
10.3760/cma.j.issn.0254-1416.2016.12.008
- VernacularTitle:盐酸纳美芬预防全麻诱导时舒芬太尼诱发咳嗽的效果
- Author:
Chenhui LIU
;
Maochun LIU
;
Zongze ZHANG
- Keywords:
Receptors,opioid;
Sufentanil;
Cough;
Anesthesia,general
- From:
Chinese Journal of Anesthesiology
2016;36(12):1441-1443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of nalmefene in preventing sufentanil-induced cough during induction of general anesthesia.Methods One hundred American Society of Anesthesiologists physical status Ⅰ orⅡ patients of both sexes,aged 21-62 yr,weighing 45-82 kg,undergoing elective laparoscopic cholecystectomy under general anesthesia,were divided into 2 groups (n =50 each) using a random number table:nalmefene group (group N) and control group (group C).Nalmefene 0.25 μg/kg was injected intravenously at 2 min before anesthesia induction in group N,and the equal volume of normal saline was given instead in group C.Anesthesia was induced with target-controlled infusion of propofol,and sufentanil 0.5 μg/kg was injected over 5 s when bispectral index value reached 55.The number of patients who developed cough within 2 min after sufentanil injection and severity of cough were observed.Other iv anesthetics were given for induction after the end of observation.Results The incidence of sufentanil-induced cough was 8％ in group N and 48％ in group C.Compared with group C,the incidence and severity of cough were significantly decreased in group N (P＜0.05).Conclusion Nalmefene 0.25 μg/kg injected at 2 min before induction of anesthesia can effectively decrease the development of sufentanil-induced cough during induction of general anesthesia.
