Change and significance of serum HO-1/CO system level in patients with coronary heart disease complicating heart failure
10.3969/j.issn.1671-8348.2017.10.014
- VernacularTitle:冠心病合并心力衰竭患者血清HO-1/CO系统水平变化及其意义
- Author:
Lian QIN
;
Guihua LI
;
Zhong WANG
;
Zhong HUANG
;
Xiaoli ZHANG
- Keywords:
heart failure;
chronic disease;
heme oxygenase (decyclizing);
nitric oxide
- From:
Chongqing Medicine
2017;46(10):1343-1345
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the difference of serum heme oxygenase-1 (HO-1) and carbon monoxide(CO) levels between the patients with coronary heart disease(CHD) caused chronic heart failure(CHF) and CHD patients with normal cardiac function,and further to explore the protective mechanism of HO-1/CO system during the pathogenesis process of CHF.Methods Ninety-one patients with CHF were selected as the observation group and 72 CHD cases with normal cardiac function were taken as the control group.The concentration of HO-1 was determined by ELISA arid the Chalmer S method was used to detect serum CO concentration.The general clinical data of the two groups were recorded by the using the heart failure questionnaire.And the liver and kidney functions,blood lipids,NT-proBNP,BNP and cardiac echocardiography examination were performed.Results The serum HO-1 level in the observation group was (8.13±0.27)ng/mL,which was higher than (2.80±0.52)ng/mL in the control group;the CO level in the observation group was (0.35±0.06)mg/L,which was lower than(0.59±0.07)mg/L in the control group,the difference was statistically significant(P＜0.01);the HO-1 level in the observation group was gradually increased with the increase of cardiac function grade (P＜0.01);while the CO level was decreased with the increase of cardiac function grade (P＜0.01).Conclusion The serum HO-11evel in the patients with CHF is highly expressed with the heart failure aggravation;endogenous CO is gradually decreased due to consumption after cardiac failure aggravation.
