Expression and significance of ArhGAP29 and E-cadherin in intrauterine adhesions of endometrium
10.13315/j.cnki.cjcep.2017.01.002
- VernacularTitle:宫腔粘连子宫内膜组织中ArhGAP29、E-cadherin的表达及意义
- Author:
Qian XU
;
Hua DUAN
;
Sha WANG
;
Lu GAN
;
Fengxian FU
;
Yiqun TANG
- Keywords:
intrauterine adhesions;
ArhGAP29;
E-cadherin;
epithelial-mesenchymal transition;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(1):4-7
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression and significance of ArhGAP29 and E-cadherin in endometrial tissue of intrauterine adhesions (IUAs) and to explore their roles in the pathogenesis of IUAs.Methods The expression of ArhGAP29 and E-cadherin was detected by immunohistochemical PV 9000 two-step method.The correlation between ArhGAP29 and E-cadherin expression and clinical features was analyzed.Results (1) The immunoreactive score (IRS) of ArhGAP29 and E-cadherin in normal endometrial tissue were higher than those in IUAs endometrial tissue (P =0.017,P =0.004).(2) IRS of ArhGAP 29 and E-cadherin in moderate IUAs patients were higher than that in severe IUAs patients (P =0.020,P =0.026).In IUAs patients without amenorrhea,the IRS of ArhGAP29 and Ecadherin were higher (P =0.019,P =0.031) than that in IUAs patients with amenorrhea.(3) The decrease of ArhGAP29 expression had a significantly parallel relationship with the negative expression of E-cadherin (r =0.725,P ＜ 0.001).Conclusion The expression of ArhGAP29 and E-cadherin decreases in endometrial tissue of IUAs patients,which is related with degree of IUAs severity.ArhGAP29 and E-cadherin may participate in the IUAs formation.
