Analysis on changes of drug resistance and class Ⅰ integron in clinically isolated Pseudomonas aeruginosa during 2013-2015
10.3969/j.issn.1673-4130.2017.07.007
- VernacularTitle:2013-2015年临床分离铜绿假单胞菌耐药性及Ⅰ类整合子变化分析
- Author:
Ming YANG
;
Yanghui QIAN
;
Qiangyuan ZHAO
- Keywords:
pseudomonas aeruginosa;
class Ⅰ integron;
drug resistance
- From:
International Journal of Laboratory Medicine
2017;38(7):886-889
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of drug resistance and class Ⅰ integron in clinically isolated Pseudomonas aeruginosa(PA) in our hospital form January 2013 to December 2015.Methods Clinically isolated PA strains were divided into the 3 time periods of 2013,2014 and 2015.Their resistance to 22 commonly used antibacterial drugs was investigated by adopting the VITEK-2;200 strains were randomly selected from the isolated strains during these 3 time periods.Class Ⅰ integron was detect by PCR.Results The detected PA in these 3 time periods had 366,437 and 520 strains respectively.The drug resistance of Pseudomonas aeruginosa to 22 commonly used antibacterial drugs was remarkably increased(P<0.05),especially in ICU.The detection rate of class Ⅰ integron positive bacteria was gradually increased year by year,moreover the drug resistance rate of class Ⅰ integron positive bacteria was significantly higher than that of class Ⅰ integron negative bacteria (P<0.01).Conclusion The drug resistance rate of PA in this hospital is higher.The proportions of multi-drug resistance and classⅠ integron are significantly increased.The hospital infection detection and drug-resistant bacterial monitoring should be strengthened to further standardize the use of antibacterial drugs.
