Safety of Intra-articular Injection of Bevacizumab in the Knee Joint of Rabbit

VernacularTitle:贝伐单抗在兔膝关节腔内注射的安全性
Author: Wei LI ; Chunyan JIANG ; Zhanwei WANG ; Xiao WU ; Deming XIAO
Keywords: Bevacizumab; Knee joint; Injection; intraarticular
From: Herald of Medicine 2017;36(5):493-496
CountryChina
Language:Chinese
Abstract: Objective To evaluate the toxicity of the intra-articular injection of bevacizumab in the knee of the rabbit.Methods Thirty-two rabbits were divided into 3 experimental groups and normal control group.Three experimental groups were received intra-articular injection of bevacizumab (1, 2, 4 mg respectively) once every three weeks for two times and the normal control group was received the same amount of 0.9% sodium chloride solution.The animals were sacrificed after 6 weeks.Blood test was examined before and after treatment.Pathologic examinations of liver, kidney and artiluar tissue were taken after the sacrifice.The hematoxylin and eosin stain for synovium and cartilage were performed.The AB-PAS stain and Mankin's scale for cartilage were performed.Results All the rabbits kept normal physiological activity.There was no significant difference of major organs and articular tissue between experimental groups and normal control group.There was no significant difference for WBC, RBC, PLT, ALT, BUN and Mankin's scale among all groups.Conclusion No systemic toxicity effects were found for the intra-articular injection of bevacizumab in the knee of the rabbit.