Research progress of AIM2 in tumor
10.11904/j.issn.1002-3070.2017.02.016
- VernacularTitle:AIM2在肿瘤中的研究进展
- Author:
Lixiao HAO
- Keywords:
AIM2;
Malignant tumor;
Inflammasome
- From:
Practical Oncology Journal
2017;31(2):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Absent in melanoma 2(AIM2),as a cytoplasmic DNA sensor,can perceive the cytoplasmic dsDNA which released by the cells infected with DNA virus or bacteria.AIM2 will be raised by Apoptosis-associated speck-like protein containing a CARD to produce inflammation complex,activate of Caspase-1,promote the maturation,and secretion of IL-1β and IL-18,or lead to pyroptosis.AIM2 plays an importation role in initiating immunity.Recent research shows that AIM2 has an influence on the occurrence and progress in tumor,it acts as a tumor suppressor and inhibits tumor progression in liver and breast carcinoma;However,AIM2 shows the carcinogenic effect of promoting tumor development on cervical carcinoma and oral squamous cell carcinoma.These results contribute to the diagnosis and prognosis of malignant tumor.
