Study on the Skin Irritation of Hongzhi Gutong Cataplasm in Rabbits
10.6039/j.issn.1001-0408.2017.07.08
- VernacularTitle:红栀骨通凝胶膏对家兔皮肤刺激性的研究
- Author:
Weiwen PENG
;
Zhuqiang WANG
;
Fei WU
- Keywords:
Hongzhi gutong cataplasm;
Skin irritation;
Complete skin;
Damaged skin;
Single dose;
Multiple doses;
Rabbits
- From:
China Pharmacy
2017;28(7):893-895
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the safety of percutaneous administration of Hongzhi gutong cataplasm. METHODS:Rab-bits were taken for single dose in complete skin irritation test(n=4),single dose in damaged skin irritation test(n=4)and multi-ple doses in complete skin irritation test(n=4). The left and right sides of the skin respectively paste 3 cm×3 cm blank matrix and Hongzhi gutong cataplasm for 24 h(calculated by crude drug of 0.14 g). After removing tape 1,24,48,72 h,the erythema and edema in hair removal site of rabbits in the former 2 tests were observed;after 24 h of administration,the rabbits in the last group were administrated again after exposing the administration area for 1 h,repeated 3 times,the erythema and edema in hair removal site after removing tape the first,second time and 1,24,48,72 h in the third time were respectively observed. RESULTS:In the 3 experiments,the scores of erythema and edema of all rabbits were 0,and skin irritation was evaluated as no irritation. CONCLU-SIONS:Hongzhi gutong cataplasm has no skin irritation in rabbits.
