Progress in TET enzymes and their intermediate products
10.3969/j.issn.1000-4718.2017.03.033
- VernacularTitle:TET酶及其中间产物的研究进展
- Author:
Yichen CHENG
;
Xiaoming WU
;
Ying LUO
- Keywords:
TET enzymes;
DNA demethylation;
5-methylcytosine;
5-hydroxymethylcytosine;
5-formylcy-tosine;
5-carboxylcytosine
- From:
Chinese Journal of Pathophysiology
2017;33(3):572-576
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation is an important epigenetic modification mode , which plays a crucial role in gene expression , genome stability and development .DNA methylation is catalyzed and maintained in cell proliferation by the family of DNA methyltransferases.The ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC).Here, we briefly describe the TET enzymes and their role in cancer , and the distribution , the role and detection method of those three oxidation products of cytosine in genome .
