Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen
- VernacularTitle:地衣抗癌活性部位AMH-T的毒理学
- Author:
Yunfa HE
;
Xiaoqiong HE
;
Min LIU
;
Jing WANG
;
Songshan HU
;
Jingling SHUI
;
Chongyang JIANG
- Keywords:
Lichen;
Anti-cancer drug;
Acute toxicity;
Genotoxicity;
Toxicology
- From:
Journal of Kunming Medical University
2016;37(9):26-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide safety reference for the development of anti-cancer drugs by evaluating thetoxicological safety of the anticancer bioactive fraction AMH-T of lichen through the understanding of its poisonous nature and the intensity.Methods Acute toxicity test,bone marrow micronucleus test in mice,sperm malformation test in rats,Ames test and short-term repeat drug test in mice were conducted.Results Male mice were injected LD50 of 147 mg/kg and female mice 171 mg/kg.Conclusion Injection of AMH-T has acute toxicity and liver toxicity,but has no genetic toxicity.
