Analysis of 21 Cases of Risperidone-induced Leucocytopenia ADR Reports in Our Hospital

VernacularTitle:我院21例利培酮致白细胞减少的不良反应报告分析
Author: Hongyan ZHUANG ; Shanshan LIU ; Wei GUO ; Xin MA ; Hongbing HAO ; Haixia LIANG ; Qiuyan WANG
Keywords: Risperidone; Leucocytopenia; Adverse drug reaction; Rational drug use
From: China Pharmacy 2017;28(8):1052-1055
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To analyze the features of risperidone-induced leucocytopenia ADR.METHODS:Twenty-one ADR cases of risperidone-induced leucocytopenia reported by our hospital were collected and analyzed during 2004-2015.The characteris tics of risperidone-induced leucocytopenia were discussed.RESULTS:Among 21 patients,there were 10 male and 11 female.The age was from 15 to 72 years old.Nine cases of patients were 31-40 years old (42.9％).Most of the original disease was schizophre nia.Incubation period of leucocytopenia caused by risperidone was (28.6 ± 21.4) d.Patients had no discomfort complain when leucocytopenia occurred.The lowest white blood cells reported was(3.1 ± 0.5)× 109 L-1.The leucocytopenia were improved after reduc tion,drug withdrawal and symptomatic treatment.CONCLUSIONS:Patients usually have no body discomfort complain when risperidone-induced leucocytopenia appears.Doctors should moniter ADR regularly,identify it earlier and treat carefully.