Application of next-generation sequencing technology in forensic science
10.13618/j.issn.1001-5728.2017.01.011
- VernacularTitle:二代测序技术在法医学中的应用
- Author:
Wen ZHANG
;
Baowen CHENG
;
Bingying XU
- Keywords:
forensic biological evidence;
next generation sequencing;
STR;
SNP;
HLA
- From:
Chinese Journal of Forensic Medicine
2017;32(1):40-43
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of Next-generation Sequencing(NGS)technologies, and its high throughput and low cost is applied widely in the field of life science, the increase in the depth of sequencing together decrease in the consumption of time and cost, makes a wide application of NGS in the research of microbiological research, ancient DNA study, clinical diagnosis, forensic science research, etc. The article discusses the second generation sequencing technology platform and its genetic markers in the forensic application. Included STR typing, SNP typing, HLA genotype prediction and the application in the degradation of the material.
