Detection and significance of cytokines related to NF-κB signaling pathway in patients with different TCM syndrome types of diabetic nephropathy
10.3969/j.issn.1671-8348.2017.07.011
- VernacularTitle:DN不同中医证型NF-κB信号通路相关细胞因子的检测及意义
- Author:
Xiongyan XUE
;
Changlin ZHU
;
Lianhua PAN
;
Shaozhen HUANG
;
Weixuan LI
- Keywords:
diabetic nephropathy;
NF-kappa B;
cell signaling pathway;
cytokines;
traditional Chinese Medicine syndrome
- From:
Chongqing Medicine
2017;46(7):898-900
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression difference of cytokines related to nuclear factor kappa B (NF-κB) signaling pathway among different traditional Chinese medicine (TCM) syndromes in the patients with diabetic nephropathy (DN).Methods Serum tumor necrosis factor-α (TNF-α),interleukin-1 (IL-1),interleukin-6 (IL-6) and interleukin-8 (IL-8) in 146 patients with DN and 62 individuals undergoing healthy physical examination in the control group were measured.Results The levels of serum TNF-α,IL-1,IL-6 and IL-8 in various DN groups were significantly higher than those in the control group (P＜0.05).The levels of serum TNF-α,IL-1,IL-6 and IL-8 were significantly different among groups of different TCM syndromes (P＜0.05).With the progression of DN,all cytokines levels showed a gradually increasing trend,moreover the increased extents and time were different in different TCM syndrome types of DN.Conclusion The levels of serum TNF-α,IL-1,IL-6 and IL-8 related to NF-κB signaling pathway are correlated with different TCM syndromes types and may play a role in the occurrence and progression of different TCM syndrome types of DN.
