Progress on the cell-surface markers and signaling pathways of colorectal cancer stem cells
- VernacularTitle:结直肠癌干细胞表面标志物和信号通路研究进展
- Author:
Boyue DING
;
Chun HAN
- Keywords:
colorectal cancer;
Lgr5;
Bmi1;
Msi1;
Wnt signal;
Notch signal
- From:
Basic & Clinical Medicine
2017;37(1):133-137
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal stem cells have many bio-markers, including Lgr5 which expression is associated with THE stage of disease , also regulating the cell cycle , anothers is +4 stem cell , which is associated with tumor heteroge-neity, also expressed Bmi1, arresting cell cycle.Besides there is Msi1.Many studies show that those markers are highly expressed in colorectal cancer , which activate Notch and Wnt signaling pathway , and can promote the pro-gress of tumor .
