Effect of curcumin on PI3K/AKT/mTOR in rats with cerebral ischemia-reperfusion injury
10.3969/j.issn.1671-8348.2017.01.006
- VernacularTitle:姜黄素对脑缺血再灌注损伤大鼠PI3K／AKT／mTOR的影响
- Author:
Jin LAN
;
Jingfang PAN
- Keywords:
curcumin;
brain ischemia;
reperfusion injury;
inflammation;
apoptosis;
oxidative stress;
PI3K/AKT/mTOR
- From:
Chongqing Medicine
2017;46(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect and mechanism of curcumin on rat cerebral ischemia reperfusion injury.Methods The rat model of cerebral ischemia reperfusion injury was constructed by the suture-occluded method.The effects of curcumin on cerebral infarction range,cerebral water content,neurological symptoms,cerebral histopathological morphology and expressions of PI3K,AKT,p-AKT,m-TOR,MDA,CAT,GPX,SOD,Bcl-2,Bax,Caspase-3 and Cleavage-Caspase-3 were evaluated.Results Cur-cumin had the protective effect on cerebral ischemia reperfusion injury,could alleviate the neurological symptoms,decreased the cer-ebral tissue pathological morphological changes and cerebral water content,in addition,which could alleviate the expressions of MDA,Bax,Cleavage-Caspase-3,IL-6,MCP-1 and TNF-αand increased the expressions of PI3K,p-AKT,mTOR,Bcl-2,Caspase-3, CAT,GPX and SOD.Conclusion The curcumin pretreatment has the significantly protective effect on cerebral ischemia-reperfusion injury,which may be associated with activating PI3K/AKT/mTOR signal pathway,while suppressing inflammation,apoptosis and oxidative stress.
