Preparation and Properties of Mesalazine β-Cyclodextrin Inclusion Compound
- VernacularTitle:美沙拉嗪-β-环糊精包合物的制备及其性质研究
- Author:
Chunling JIANG
;
Conghai LIU
;
Chenggui ZHANG
;
Hengyuan XIE
;
Guangya CAI
;
Ya ZHOU
;
Shi CHEN
- Keywords:
Mesalazine;
β-Cyclodextrin;
Inclusion compound;
Thermodynamics;
Bioavailability
- From:
China Pharmacist
2017;20(2):266-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare mesalazineβ-cyclodextrin inclusion compound and observe its properties. Methods:The struc-ture was characterized by UV, IR and DSC. The inclusion process of mesalazine andβ-cyclodextrin was simulated using molecular doc-king technique. The solubility and dissolution of inclusion compound were determined. Results:UV, IR and DSC were used to deter-mine the formation of inclusion complex. The inclusion ratio was 1: 1 and the phase solubility diagram was AL type. The solubility of inclusion compound in deionized water (25 ℃, pH 7. 0) was 7. 8 mg·ml-1 . The preparation of mesalazine β-cyclodextrin inclusion compound could significantly increase the dissolution rate and solubility of mesalazine. Conclusion:The prepared mesalazineβ-cyclo-dextrin inclusion compound can obviously improve the poor water solubility and dissolution of mesalazine.
