Preliminary study on plasma metabolites of total body irradiation patients

VernacularTitle:需行全身照射患者辐射损伤血浆代谢谱的研究
Author: Mingxiao ZHAO ; Xiebing BAO ; Huaiyuan CHEN ; Xiaojin WU ; Chang WANG
Keywords: Total body irradiation ( TBI ); Radiation damage; Metabonomics; Gas chromatography-mass spectrometry ( GC-MS); Plasma
From: Chinese Journal of Radiological Medicine and Protection 2017;37(1):7-11
CountryChina
Language:Chinese
Abstract: Objective To investigate radiation-related human plasma metabolic features by using metabonomics method and to analyze relative metabolic pathway .Methods The plasma samples of 40 patients pre-and post-total body irradiation (TBI) from January 2012 to May 2014 were collected, and the effect of TBI on human plasma metabolites was studied by gas chromatography mass spectrometry ( GC-MS) , and the differential plasma metabolic features related to irradiation damage were screened . Results The levels of glucose, myristic acid, oxalic acid, 3-hydroxy butyric acid, urea, aspartic acid, valine, leucine, lysine and threonine in plasma were significantly (P<0.05) increased after TBI, while the levels of cholesterol, pyruvic acid, propionic acid, lactic acid, alanine, glycine, inositol, sorbitan, ethylene glycol and hypoxanthine were decreased drastically (P<0.05).Conclusions TBI could cause significant changes in the levels of human plasma metabolites including amino acid metabolism , glucose metabolism, lipid metabolism and so on.