Fibrillary glomerulonephritis combined with chronic inflammatory demyelinating polyneuropathy.
10.1016/j.krcp.2014.10.008
- Author:
Woo Kyung SUNG
1
;
Jin Uk JEONG
;
Ki Tae BANG
;
Jong Ho SHIN
;
Ji Hyung YOO
;
Nak Min KIM
;
Jun Hyung PARK
;
Joo Heon KIM
Author Information
1. Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea. jjo9428@eulji.ac.kr
- Publication Type:Case Report
- Keywords:
Fibrillary glomerulonephritis;
Monoclonal gammopathy;
Polyneuropathy
- MeSH:
Amyloid;
Basement Membrane;
Bence Jones Protein;
Biopsy;
Capillaries;
Congo Red;
Edema;
Electromyography;
Fluorescent Antibody Technique;
Glomerulonephritis*;
Immunoelectrophoresis;
Immunoglobulin A;
Immunoglobulin M;
Immunoglobulins;
Leg;
Lower Extremity;
Monoclonal Gammopathy of Undetermined Significance;
Neural Conduction;
Paraproteinemias;
Polyneuropathies*
- From:Kidney Research and Clinical Practice
2015;34(2):117-119
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 58-yr-old man presented with leg edema and subacute weakness of his bilateral lower extremities. Urinary and serum immunoelectrophoresis revealed the presence of lambda-type Bence Jones proteins. He was ultimately diagnosed with monoclonal gammopathy of undetermined significance (MGUS). A renal biopsy specimen showed fibrillary glomerulonephritis (FGN), which was randomly arranged as 12-20 m nonbranching fibrils in the basement membranes. Immunofluorescence studies were negative for immunoglobulin (Ig)G, IgM, IgA, C3, and kappa light chains in the capillary walls and mesangial areas. A Congo red stain for amyloid was negative. Electromyography and nerve conduction velocity examinations results were compatible with the presence of demyelinating polyneuropathy. This case showed a rare combination of FGN, without Ig deposition, and MGUS combined with chronic inflammatory demyelinating polyneuropathy (CIDP).
