Correlation of AS160 hyperphosphorylation and 18 F-FDG uptaking in invasive breast cancer

VernacularTitle:乳腺癌AS160分子高磷酸化与18F-FDG摄取相关性研究
Author: Yu WEI ; Xiaohua JIANG ; Ning MA ; Yi CHENG ; Guifang LYU ; Wei WANG ; Jinfen ZHAO
Keywords: Breast neoplasms; Phosphorylation; Fluomdeoxyglucose F18; AS160
From: Journal of International Oncology 2017;44(3):173-176
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between AS160 hyperphosphorylation and 18Ffluorodeoxyglucose (18F-FDG) uptaking in invasive breast cancer.Methods Thirty-nine primary breast caner patients received PET/CT scan before operation and their maximum standard uptake values (SUVmax) were recorded.The levels of p-AS160 (Thr642) were detected using immunohistochemical method in breast cancer tissues.The association between p-AS160 (Thr642) levels and SUVmax was assessed using the Spearman nonparametric test.Results The 18F-FDG uptake of tumors of the 39 patients with primary breast caner was 6.1 ± 2.7 (SUVmax).There was one false negative case in PET/CT scan imaging,compared with postoperative pathologic result.The positive rate of p-AS160 (Thr642) was 76.9％,and it was positively correlated with SUVmax (r =0.672,P ＜ 0.001).Conclusion AS160 plays a significant role in the glucose metablism of breast cancer tissues and its hyperphosphorylation may contribute to the increased uptaking of glucose in patients with breast cancer.