Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension.
10.4070/kcj.2016.46.6.827
- Author:
Tolga CIMEN
1
;
Murat BILGIN
;
Ahmet AKYEL
;
Mehmet Ali FELEKOĞLU
;
Ali NALLBANI
;
Seyda OZDEMIR
;
Gönül ERDEN
;
Alpaslan OZTÜRK
;
Mehmet DOĞAN
;
Ekrem YETER
Author Information
1. Department of Cardiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey. drtolgacim@hotmail.com
- Publication Type:Original Article
- Keywords:
Blood pressure monitoring, ambulatory;
Hypertension;
Dipping pattern;
Endocan
- MeSH:
Blood Pressure;
Blood Pressure Monitoring, Ambulatory;
C-Reactive Protein;
Enzyme-Linked Immunosorbent Assay;
Humans;
Hypertension*;
Logistic Models;
Plasma
- From:Korean Circulation Journal
2016;46(6):827-833
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Non-dipper hypertension is frequently accompanied by endothelial dysfunction and activation. Previous studies suggested that endocan may be a novel endothelial dysfunction marker. This study aims to investigate the association between circadian blood pressure (BP) pattern and plasma endocan levels together with high-sensitivity C-reactive protein (hsCRP) in patients with newly diagnosed untreated hypertension. SUBJECTS AND METHODS: Twenty-four hour ambulatory blood pressure monitoring was recorded in 35 dipper, 35 non-dipper hypertensives and 35 healthy controls. Endocan levels were measured by enzyme-linked immunosorbent assay. Serum levels of hsCRP were also recorded. RESULTS: Despite similar daytime and 24-hour average BP values between dippers and non-dippers, statistically significant high nocturnal BP was accompanied by a non-dipping pattern (Systolic BP: 132±9 vs. 147±11 mmHg; Distolic BP: 80±7 vs. 91±9 mmHg, respectively, p<0.001 for both). Non-dipper patients demonstrated higher endocan levels compared to dippers and normotensives (367 (193-844) pg/mL, 254 (182-512) pg/mL and 237 (141-314) pg/ml, respectively, p<0.001). HsCRP levels were significantly higher in non-dippers than the other groups (p=0.013). In a multivariate logistic regression analysis, endocan (p=0.021) and hsCRP (p=0.044) were independently associated with a non-dipping pattern. CONCLUSION: Elevated endocan levels were found in non-dipper groups. Endocan and hsCRP were found to be independently associated with a non-dipping pattern. We suggest that elevated levels of endocan in non-dipper hypertensive patients might be associated with a longer duration of exposure to high BP. These results point to the possible future role of endocan in selection of hypertensive patients at higher risk or target organ damage.
