Expression level and its clinical significance of human epidermal growth factor receptor 2, estrogen receptor, progesterone receptor, P53 and Ki-67 in breast cancer tissues of elderly patients
10.3760/cma.j.issn.0254-9026.2017.02.013
- VernacularTitle:老年乳腺癌组织中表皮生长因子受体2、雌激素受体、孕酮受体、P53和Ki67的表达及其临床意义
- Author:
Tanwei FANG
;
Ruifa FENG
;
Wei CHENG
- Keywords:
Breast neoplasms;
Tumor markers,biological
- From:
Chinese Journal of Geriatrics
2017;36(2):173-176
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the expression level and its clinical significance of human epidermal growth factor receptor 2 (C-erbB-2),estrogen receptor (ER),progesterone receptor (PR),Ki67 and P53 in breast cancer tissues of elderly patients.Methods The expressions of C-erbB-2,ER,PR,Ki67 and P53 in 103 specimens of breast cancer tissues were assessed by immunohistochemistry(S-P),and their relationships with clinicopathological factors including tumor size,lymph node metastasis status and clinical stages were statistically analyzed.Results The positive rate of C-erbB-2,ER,PR,Ki67 and P53 in 103 cases was 17.5％ (18/103),64.1％ (66/103),54.4 ％ (56/103),70.9 ％ (73/103) and 66.0 ％ (68/103),respectively.The positive expression rates of C-erbB-2 and P53 were correlated with clinical stages and lymph node metastasis status(P＜0.05).The positive expression rate of Ki67 was correlated with clinical stages(P＜0.05),but not correlated with tumor size and lymph node metastasis status(P＞0.05).The positive expression rates of C-erbB-2,P53,ER and PR were irrelevant to tumor size(P＞0.05).Conclusions The expression of C-erbB-2,ER,PR,Ki67 and P53 could be biological markers for estimating the occurrence and progression of elderly breast cancer.Detection of C-erbB-2,ER,PR,Ki67 and P53 may help judge the clinical stages and lymph node metastasis status in elderly patients with breast cancer.
