Interferon therapy after curative surgical intervention to improve prognosis in patients with hepatitis C-related hepatocellular carcinoma: a Meta-analysis
10.3760/cma.j.issn.1007-8118.2016.12.004
- VernacularTitle:丙型病毒性肝炎相关性肝细胞癌患者根治性外科干预后使用干扰素的Meta分析
- Author:
Guangming XIANG
;
Xiaolun HUANG
;
Yutong YAO
;
Le LUO
;
Guan WANG
;
Haibo ZOU
- Keywords:
Hepatitis C virus;
Hepatocellular carcinoma;
Interferon;
Recurrence
- From:
Chinese Journal of Hepatobiliary Surgery
2016;22(12):805-809
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of interferon therapy after curative surgical intervention on improving prognosis of patients with hepatitis C-related hepatocellular carcinoma (HCC).Methods We searched randomized clinical trials from 1990 to 2015 on interferon therapy after curative surgical intervention in patients with hepatitis C-related HCC from the Cochrane Library,the Cochrane Database of Systematic Reviews,MEDLINE and Embase.A Meta-analysis was carried out using Revman 5.Results There were 7 studies included in this research.The results showed that interferon therapy after curative surgical intervention in patients with hepatitis C-related HCC reduced the recurrence rate of HCC at 3 years (RR =0.84,95％ CI 0.73 ～0.97,P ＜0.05).The therapy could not improve the 3-year survival rate in these patients (RR =1.04,95％ CI 0.90 ～ 1.21,P ＞ 0.05).Stratified subgroup analyses showed interferon therapy after liver resection reduced the recurrence rate (RR =0.62,95 ％ CI 0.39 ～ 1.00,P =0.05).For patients with tumors less than 3 cm,interferon therapy reduced the recurrence rate (RR =0.82,95％ CI 0.69 ～ 0.98,P ＜ 0.05).Conclusion Interferon therapy after curative surgical intervention improved prognosis in patients with hepatitis C-related HCC.
